Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Aluminum Speciation in Human Serum

  • Janez ŠčančarEmail author
  • Radmila Milačič
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_106

Synonyms

Definition

The role of trace elements and their impact on the environment and living organisms depend not only on their total concentration but also on chemical forms in which they are actually present. Individual chemical species of trace elements in different samples are quantitatively determined by speciation analysis.

A fundamental tool for speciation analysis of aluminum (Al) is the combination of separation technique coupled to element-specific detector. For the time being the most powerful hyphenation is coupling of liquid chromatography to inductively coupled plasma mass spectrometry (ICP-MS). For identification of Al-binding ligands, mass spectrometry (MS)-based techniques exhibit the greatest potential.

Introduction

Al is the most abundant metal in the lithosphere, comprising 8% of the Earth’s crust. The sparingly soluble nature...

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References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Environmental SciencesJožef Stefan InstituteLjubljanaSlovenia