Aluminum Speciation in Human Serum
The role of trace elements and their impact on the environment and living organisms depend not only on their total concentration but also on chemical forms in which they are actually present. Individual chemical species of trace elements in different samples are quantitatively determined by speciation analysis.
A fundamental tool for speciation analysis of aluminum (Al) is the combination of separation technique coupled to element-specific detector. For the time being the most powerful hyphenation is coupling of liquid chromatography to inductively coupled plasma mass spectrometry (ICP-MS). For identification of Al-binding ligands, mass spectrometry (MS)-based techniques exhibit the greatest potential.
Al is the most abundant metal in the lithosphere, comprising 8% of the Earth’s crust. The sparingly soluble nature...
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