Aluminum and Bioactive Molecules, Interaction
Interaction of aluminum and low molecular mass substances of biological interest is a phenomenon that may explain the effects of aluminum in the environment and organisms.
Aluminum [Al(III)] is a potential neurotoxic agent implicated in the pathogenesis of many neurological disorders (Yokel et al. 2001). The possible role of Al(III) in the development of pathologies, such as Alzheimer’s disease, has often been investigated. The interaction of this element with biologically related sites, represented by proteins, enzymes, and coenzymes as well as enzyme-active sites and low molecular mass organic substrates, is prevalent in biological fluids.
Al-α-KG: Constitutional Aspect
Alpha-Ketoglutate (α-KG) is common in many microorganisms, and can also be isolated from higher plants.