Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Aluminum and Bioactive Molecules, Interaction

  • Xiaodi YangEmail author
  • Huihui Li
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_104

Synonyms

Definition

Interaction of aluminum and low molecular mass substances of biological interest is a phenomenon that may explain the effects of aluminum in the environment and organisms.

Aluminum [Al(III)] is a potential neurotoxic agent implicated in the pathogenesis of many neurological disorders (Yokel et al. 2001). The possible role of Al(III) in the development of pathologies, such as Alzheimer’s disease, has often been investigated. The interaction of this element with biologically related sites, represented by proteins, enzymes, and coenzymes as well as enzyme-active sites and low molecular mass organic substrates, is prevalent in biological fluids.

Al-α-KG: Constitutional Aspect

Alpha-Ketoglutate (α-KG) is common in many microorganisms, and can also be isolated from higher plants.

The α-KG was found to bind Al(III) in a bidentate manner at the carboxylate and carbonyl moieties. The mononuclear 1:1...
This is a preview of subscription content, log in to check access.

References

  1. Delonce R, Fauconnrau B, Piriou A, Huguet F, Guillard O (2002) Aluminum L-glutamate complex in rat brain cortex: in vivo prevention of aluminum deposit by magnesium D-aspartate. Brain Res 946:247–252CrossRefGoogle Scholar
  2. Murakami K, Yoshino M (2004) Aluminum decreases the glutathinoe regeneration by the inhibition of NADP-isocitrate dehydrogenase in mitochondria. J Cell Biochem 93:1267–1271PubMedCrossRefGoogle Scholar
  3. Wang XL, Li K, Yang XD, Wang LL, Shen RF (2009) Complexation of Al(III) with reduced glutathione in acidic aqueous solutions. J Inorg Biochem 103:657–665PubMedCrossRefGoogle Scholar
  4. Yang XD, Bi SP, Wang XL, Liu J, Bai ZP (2003a) Multimethod characterization of the interaction of aluminum ion with α-ketoglutaric acid in acidic aqueous solutions. Anal Sci 19:273–279PubMedCrossRefGoogle Scholar
  5. Yang XD, Bi SP, Yang L, Zhu YH, Wang XL (2003b) Multi-NMR and fluorescence spectra study the effects of aluminum(III) on coenzyme NADH in aqueous solutions. Spectrochim Acta A 59:2561–2569CrossRefGoogle Scholar
  6. Yang XD, Bi SP, Yang XL, Yang L, Hu J, Liu J (2003c) NMR spectra and potentiometry studies of aluminum(III) binding with coenzyme NAD+ in acidic aqueous solutions. Anal Sci 19:815–821PubMedCrossRefGoogle Scholar
  7. Yang XD, Tang YZ, Bi SP, Yang GS, Hu J (2003d) Potentiometric and multi-NMR studies of aluminum(III) complex with L-glutamate in acidic aqueous solutions. Anal Sci 19:133–138PubMedCrossRefGoogle Scholar
  8. Yang XD, Zhang QQ, Li LF, Shen RF (2007) Structural features of aluminium(III) complexes with bioligands in glutamate dehydrogenase reaction system – a review. J Inorg Biochem 101:1242–1250PubMedCrossRefGoogle Scholar
  9. Yang XD, Zhang QQ, Chen RF, Shen RF (2008) Speciation of aluminum(III) complexes with oxidized glutathione in acidic aqueous solutions. Anal Sci 24:1005–1012PubMedCrossRefGoogle Scholar
  10. Yokel RA, Rhineheimer SS, Sharma P, Elmorce D, McNamara PJ (2001) Entry, half-life, and desferrioxamine-accelerated clearance of brain aluminum after a single (26)Al exposure. Toxicol Sci 64:77–82PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.School of Chemistry and Material ScienceNanjing Normal UniversityNanjingChina