Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Aluminum and Bioactive Molecules, Interaction

  • Xiaodi YangEmail author
  • Huihui Li
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_104



Interaction of aluminum and low molecular mass substances of biological interest is a phenomenon that may explain the effects of aluminum in the environment and organisms.

Aluminum [Al(III)] is a potential neurotoxic agent implicated in the pathogenesis of many neurological disorders (Yokel et al. 2001). The possible role of Al(III) in the development of pathologies, such as Alzheimer’s disease, has often been investigated. The interaction of this element with biologically related sites, represented by proteins, enzymes, and coenzymes as well as enzyme-active sites and low molecular mass organic substrates, is prevalent in biological fluids.

Al-α-KG: Constitutional Aspect

Alpha-Ketoglutate (α-KG) is common in many microorganisms, and can also be isolated from higher plants.

The α-KG was found to bind Al(III) in a bidentate manner at the carboxylate and carbonyl moieties. The mononuclear 1:1...
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.School of Chemistry and Material ScienceNanjing Normal UniversityNanjingChina