The corpus callosum is an interhemispheric structure that permits the integration of motor, sensory, and cognitive performance between the two cerebral hemispheres. Agenesis/dysgenesis of the corpus callosum is among the most common brain developmental malformation with a wide spectrum of associated clinical and pathologic abnormalities. The prevalence and clinical significance are uncertain. It is estimated to be 0.3–0.7% in the general population and 2–3% in the developmentally disabled (Jeret et al. 1985).
Synonyms and Related Disorders
Agenesis of corpus callosum; Dysgenesis of corpus callosum
Genetics/Basic Defects
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Markedly heterogeneous etiology of agenesis/dysgenesis of the corpus callosum (Dobyns 1996)
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Sporadic in most cases
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Environmental factors
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Alcoholism
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Maternal rubella
- iii.
Maternal diabetes
- i.
- c.
A multifactorial trait
- d.
As a part of autosomal dominant syndrome
- i.
Agenesis/dysgenesis of the corpus callosum
...
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- a.
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References
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(2012). Corpus Callosum Agenesis/Dysgenesis. In: Chen, H. (eds) Atlas of Genetic Diagnosis and Counseling. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1037-9_58
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DOI: https://doi.org/10.1007/978-1-4614-1037-9_58
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-1036-2
Online ISBN: 978-1-4614-1037-9
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