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Behcet Disease

Reference work entry

In 1937, Behçet first described three patients with oral and genital ulceration and hypopyon. It is most common in the Middle and Far East with a prevalence of 7–8 per 100,000 people, whereas in the United States the prevalence is estimated at 4 per 1,000,000 people.

Synonyms and Related Disorders

Behcet syndrome

Genetics/Basic Defect

  1. 1.

    A complex multisystem inflammatory disease of unknown cause

     
  2. 2.
    Considered a relapsing and remitting vasculitis of the small- to medium-sized vessels with following protean manifestations:
    1. a.

      Aphthous stomatitis

       
    2. b.

      Genital ulceration

       
    3. c.

      Uveitis

       
    4. d.

      Synovitis

       
    5. e.

      Gastrointestinal lesions

       
    6. f.

      Cutaneous lesions

       
    7. g.

      Central nervous system lesions

       
    8. h.

      Cardiac lesions

       
    9. i.

      Vessel lesions

       
     
  3. 3.
    Immunopathogenic aspects of Behcet disease (Direskeneli 2001; Krause and Weinberger 2008)
    1. a.

      Neutrophil activation

       
    2. b.

      Cellular and humoral immunity

       
    3. c.
      Antigenic stimuli
      1. i.

        Herpes simplex virus

         
      2. ii.

        Streptococci and superantigens

         
      3. iii.

        Heat shock...

Keywords

Anterior Uveitis Genital Ulcer Behcet Disease Posterior Uveitis Retinal Vasculitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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