Neural Tube Defects
Neural tube defects (NTDs) are among the most common severe congenital malformations of the central nervous system. Approximately 1 in 500 to 1 in 1,000 pregnancies result in NTDs. About 4,000 fetuses are affected each year in the USA. The incidence varies with geographic areas and ethnic groups. The incidence, however, appears to be decreasing recently.
Synonyms and Related Disorders
Anencephaly; Cranial meningocele; Cranio/spinal rachischisis; Cranium bifidum occultum; Encephalocele; Iniencephaly; Spina bifida
Caused by a defect in closure of the neural tube, which is normally closed by 28 days
Etiology: complex, involving environmental and genetic factors that interact to modulate the incidence and severity of the developing phenotype.
Specific causes are identified in less than 10% of affected infants.
Single gene mutations
Defects in the neural tube closure linked to...
KeywordsFolic Acid Cavitation Carbamazepine Hydrocephalus Homocysteine
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