Aplasia Cutis Congenita
Aplasia cutis congenita (ACC) is a clinical description of the absence of the skin at birth, first described by Cordon in 1767. It is a heterogeneous group of disorders characterized by absence of epidermis, dermis, and, sometimes, subcutaneous tissue, muscle, or bone on one or more parts of the body. The incidence is estimated to be 1 in 10,000 births.
Synonyms and Related Disorders
Aplasia cutis congenita associated with epidermolysis bullosa (simplex, junctional, dystrophic); Congenital scalp defect; Congenital skull and scalp defect
Amniogenic theory (Frieden 1986)
Adhesion of the amniotic membrane to the fetal skin might tear off, leaving absent areas of skin
Not supported by the study of placentas because most placentas are normal
Vascular theory: assumes thromboplastic material from a fetus papyraceus (mummified dead fetus) as the causes of skin damage
Biomechanical forces on the...
KeywordsBiliary Atresia Epidermolysis Bullosa Gonadal Dysgenesis Ectodermal Dysplasia Pyloric Atresia
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