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Stepharine (Stefaglabrine)

Reference work entry

CAS Registry Number: 2810-21-1 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Isoquinoline Alkaloids

Biological sources: Stephania glabra

C18H19NO3: 297.1365

Mp: 179–180°C, 235°C (N–Ac) [1]

[α]D +143° (CHCl3) [1], [α]D –80° (CHCl3) [1]

UV: 209, 232, 284(4.53, 4.35, 3.35) [2]

IR: 3250, 1660, 1620 [2]

MSm/z: 297(M+, 100), 296(43), 282(4), 268(63), 266(5) [3]; 297(M+, 100), 296(43), 268(65), 253(15), 237(15), 225(13) [3]

Pharm./Biol.: LD50 245 mg/kg (i/v, mice). Hypotensive action, anticholinesterase activity [4]. (Sulfate) is used in diseases of the peripheral nervous system. Supplied in 1 ml ampules of 0.25% soln. [5]

References

  1. 1.
    M.P. Cava, K. Nomura, R.H. Schlessinger, K.T. Buck, B. Douglas, R.F. Raffauf, J.A. Weisbach, Chem. Ind. 282 (1964)Google Scholar
  2. 2.
    A.N. Tackie, D. Dwuma-Badu, P.A. Lartey, P.L. Schiff, J.E. Knapp, D.J. Slatkin, J. Nat. Prod. 37, 6 (1974)Google Scholar
  3. 3.
    S.C. Flor, N.J. Doorenbos, G.H. Svoboda, J.E. Knapp, P.L. Schiff, J. Pharm. Sci. 63, 618 (1974)Google Scholar
  4. 4.
    V.V. Berezhinskaya, E.A. Trutneva, Trudy VILR 14, 66 (1971)Google Scholar
  5. 5.
    M.D. Mashkovskii, Drugs [in Russian], vol. 1 (Meditsina, Moscow, 1984), p. 229Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

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