Advertisement

(±) – Salsoline

Reference work entry

Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Isoquinoline Alkaloids

Biological sources: Salsola richteri

C11H15NO2: 193.1099

Mp: 217–219°C, 203°C (hydrochloride), 195°C (picrate), 233°C (picrolonate) [1]

[α]D

UV: 226, 285(3.79, 3.55) [2]

IR: 3280, 1608, 1535, 1323, 1302, 1263, 1254, 1220, 1181, 1137, 1118, 1099, 1067, 1042, 1030, 1012, 923, 867, 841, 811, 798, 743, 732, 720 [2]

MSm/z: 193(M+, 3), 192(12), 178(100), 164(5), 163(17), 149(11), 134(7), 122(6), 43(25) [3]

1H NMR: 1.38(3H, d, 1-CH3), 3.88(3H, s, OCH3), 4.16(1H, d, H-1), 6.22(2H, s, H-5, H-8)

Pharm./Biol.: LD50(hydrochloride) 370 mg/kg. Small doses cause transitory hypertension. High doses lower pressure, stimulate respiration, and reduce diuresis with retention of chlorides. (The hydrochloride) is used in the treatment of hypertonic disease and spasms of the vessels of the brain [4]

References

  1. 1.
    A. Orechoff, E. Spath, F. Kuffner, Chem. Ber. 67, 1214 (1934)Google Scholar
  2. 2.
    J. Holubek, O. Strouf, Spectral Data and Physical Constants of Alkaloids, vol. 2 (Prague Publishing House, Czechoslovak Academy of Sciences/Heyden & Son, London, 1966). No. 239Google Scholar
  3. 3.
    M.D. Menachery, G.L. Lavanier, M.L. Wetherly, H. Guinaudeau, M. Shamma, J. Nat. Prod. 49, 745 (1986)Google Scholar
  4. 4.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 105Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

Personalised recommendations