Fugapavine (Mecambrine)

Reference work entry

CAS Registry Number: 1093-07-8 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Isoquinoline Alkaloids

Biological sources: Papaver fugax, P. maeoticum, P. persicum

C18H17NO3: 295.1208

Mp: 178–179°C [1]

[α]D−116° (CHCl3) [1]

UV: 231, 294 [1]

IR: 2735, 1667, 1607, 1592, 1490, 1462, 1365 [1]

MSm/z: 295(M+), 294, 266(100), 252, 237 [1]

1H NMR: 2.36(3H, s, NCH3), 5.76, 5.82(each 1H, d, J = 1.5, CH2O2), 6.51(1H, s), 6.15–7.10(4H, m) [1]

HPLC: [2]

Pharm./Biol.: LD50 7.015 mg/kg (s/c, mice). Analeptic of CNS [3]

References

  1. 1.
    R. Shakirov, M.V. Telezhenetskaya, I.A. Bessonova, S.F. Aripova, I.A. Israilov, M.N. Sultankhodzhaev, V.I. Akhmedzhanova, V.I. Vinogradova, T.S. Tulyaganov, B.T. Salimov, V.A. Tel’nov, Chem. Nat. Comp 32, 932 (1996)Google Scholar
  2. 2.
    M. Hutin, A. Oztekin, A. Cave, J.P. Foucher, J. Chromatogr. 265, 139 (1983)Google Scholar
  3. 3.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 227Google Scholar

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© Springer Science+Business Media New York 2013

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