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Dihydroberberine (Lambertine)

Reference work entry

CAS Registry Number: 483-15-8 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Diisoquinoline Alkaloids

Biological sources: Berberis vulgaris

C20H19NO4: 337.1314

Mp: 163–164°C [1]

Solubility: very sol. CHCl3; spar. sol. Et2O, C6H6 [1]

UV: 280, 368(4.21; 4.30) [1]

IR: 3250-3150, 1600, 1570, 1230, 1065, 1040 [2]

1H NMR(DMSO-d6): 3.05–3.60(6H, m, 3 × CH2), 4.1, 4.2(each 3H, s, 2 × OCH3), 6.15(2H, CH2O2), 7.05–9.20(H–Ar), 9.50(1H) [2]

13 C NMR(DMSO-d 6): [ 2]

Table 1

C-1

108.3

C-5

37.0

C-11

121.2

2

143.5

 6

57.7

 12

120.3

 3

145.3

 8

57.1

 12a

137.3

 4

105.3

 8a

132.9

9-OCH3

56.2

 4a

126.6

 9

149.6

10-OCH3

61.9

 4b

123.4

 10

147.5

CH2O2

101.5

References

  1. 1.
    M.M. Yusupov, A. Karimov, K.L. Lutfullin, Chem. Nat. Comp. 26, 105 (1990)Google Scholar
  2. 2.
    M.P. Dobhal, V.K. Goel, B.C. Joshi, Pharmazie 43, 659 (1988)Google Scholar

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© Springer Science+Business Media New York 2013

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