Corydaline

CAS Registry Number: 518-69-4

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Diisoquinoline Alkaloids

Biological sources: Corydalis glaucescens, C. ledebouriana, C. marschalliana, C. popovii

C₂₂H₂₇NO₄: 369.1940

Mp: 134–135°C (MeOH) [1]

[α]_D +300° (CHCl₃) [1]

UV: 227, 282 [2]

IR: 3010, 2980, 2950, 2900, 2850, 2800, 1665, 1648, 1623, 1509, 1488, 1468, 1421, 1398, 1368, 1337, 1319, 1295, 1281, 1258, 1241, 1159, 1130, 1086, 1078, 1047, 1016, 973, 962, 942, 921, 873, 858, 838, 825, 814 [3]

MS m/z: 369(M⁺), 192, 190, 178(100) [4]

¹ H NMR: 0.98(3H, d, J = 7), 3.83(3H, s, OCH₃), 3.89(9H, s, 3 × OCH₃), 6.61, 6.84(each 1H, s, 2 × H–Ar), 6.72(2H, s, H–Ar) [4, 5]

¹³ C NMR: [5]

Table 1

C-1	109.0	C-8	54.5	C-13	38.4
2	147.3	8a	128.6	14	63.1
3	147.8	9	150.2	14a	128.6
4	111.3	10	145.1	15	18.4
4a	128.5	11	111.7	2-OCH3	55.8
5	29.4	12	124.1	3-OCH3	55.9
6	51.5	12a	135.1	9-OCH3	60.1
				10-OCH3	56.2

Abs. conf.: [6]

HPLC: [7]