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Thalsimine

Reference work entry

CAS Registry Number: 5525-36-0 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Bisisoquinoline Alkaloids

Biological sources: Thalictrum simplex

C38H40N2O7: 636.2836

Mp: 140–142°C (Me2CO) [1], 235°C (dec., hydrochloride), 218°C (dec., nitrate), 171°C (dec., tartrate), 211°C (dec., picrate)

[α]D +27° (CHCl3) [1]

Solubility: very sol. EtOH, C6H6, EtOAc, CHCl3; spar. sol. pet. ether; insol. H2O, alk. [1]

UV: 278, 310(4.02, 3.76) [2]

IR: 1630-1550 [2]

MSm/z: 636(M+, 100), 635(64), 621(51), 605(17), 499(11), 235, 205(13), 190, 175(5), 174(7), 90(15) [3]

1H NMR: 3.74–3.84(5 × OCH3) [4]

Abs. conf.: 1S [5]

Pharm./Biol.: LD50 1263, 505, 69 mg/kg (s/c, i/p, i/v, mice); 358 mg/kg (i/p, rats). Hypotensive, anti-inflammatory, sedative, antispastic action [6]

References

  1. 1.
    Z.F. Ismailov, S.Kh. Maekh, S.Yu. Yunusov, DAN UzSSR (12), 22 (1960)Google Scholar
  2. 2.
    S.Kh. Maekh, S.Yu. Yunusov, Chem. Nat. Comp. 1, 144 (1965)Google Scholar
  3. 3.
    Z.F. Ismailov, S.Yu. Yunusov, Chem. Nat. Comp. 4, 220 (1968). S.Kh. Maekh, Z.F. Ismailov, S.Yu. Yunusov, Chem. Nat. Comp. 4, 335 (1968)Google Scholar
  4. 4.
    Z.F. Ismailov, M.R. Yagudaev, S.Yu. Yunusov, Chem. Nat. Comp. 4, 226 (1968)Google Scholar
  5. 5.
    G.P. Moiseeva, S.Kh. Maekh, S.Yu. Yunusov, Chem. Nat. Comp. 15, 723 (1979)Google Scholar
  6. 6.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 253Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

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