Thalmine

Reference work entry

CAS Registry Number: 7682-65-7 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Bisisoquinoline Alkaloids

Biological sources: Thalictrum collinum, T. minus

C37H40N2O6: 608.2886

Mp: 252–253°C (dec.), 157°C (dec., hydrochloride), 241°C (dec., perchlorate), 250°C (dec., methiodide) [1]

[α]D −64° (CHCl3)

Solubility: very sol. CHCl3; spar. sol. EtOH, MeOH, Me2CO, C6H6 [1]

UV: 280(3.60) [2]

IR: 3400 [3]

IR(Ac): 1770, 1195 [3]

MSm/z: 608(M+, 40), 607(23), 593(5), 577(5), 382(70), 191(100), 183(10), 175(15), 174(40), 168(30), 90(10), 89(5) [4]

1H NMR: 2.10(3H, s, 2-NCH3), 2.55(3H, s, 2′-NCH3), 3.77(3H, s, 6-OCH3), 3.83(6H, s, 2 × OCH3), 5.00(1H, OH), 5.85–6.90(10H, m, H–Ar) [5]

Abs. conf.: 1S, 1′S

Pharm./Biol.: LD50 217.5 mg/kg (i/v, mice); 3250, 372 mg/kg (per os, i/p, rats). Hypotensive, antipyretic, analgetic, anti-inflammatory [6], antitumoral [7] action

References

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    S.Yu. Yunusov, M.V. Telezhenetskaya, DAN UzSSR (5), 22 (1963)Google Scholar
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    M.V. Telezhenetskaya, S.Yu. Yunusov, DAN SSSR 162, 354 (1965)Google Scholar
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    Z.F. Ismailov, S.Yu. Yunusov, Chem. Nat. Comp. 4, 220 (1968)Google Scholar
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    Z.F. Ismailov, M.R. Yagudaev, S.Yu. Yunusov, Chem. Nat. Comp. 4, 226 (1968)Google Scholar
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    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 252Google Scholar
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    O.N. Tolkachev, Chem. Nat. Comp. 17, 195 (1981)Google Scholar

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