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Thalidasine

Reference work entry

CAS Registry Number: 16623-56-6 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Bisisoquinoline Alkaloids

Biological sources: Thalictrum longipedunculatum

C39H44N2O7: 652.3149

Mp: 105–107°C [1], 177°C (picrate) [1]

[α]D −70° (MeOH) [1]

UV: 275, 282(3.66, 3.63) [1]

MSm/z: 652(M+), 637, 621, 425, 411, 394, 213(100), 204, 190 [1]

1H NMR: 2.25(3H, s, 2-NCH3), 2.62(3H, s, 2′-NCH3), 3.27(3H, s, 7-OCH3), 3.50(3H, s, 7′-OCH3), 3.75(3H, s, 6-OCH3), 3.87(3H, s, 6′-OCH3), 3.91(3H, s, 12-OCH3) [1]

Abs. conf.: 1S, 1′S [4]

Pharm./Biol.: Antimicrobial activity [2]. Hypotensive [3], antitumoral [5] action

References

  1. 1.
    S.M. Kupchan, T.H. Yang, G.S. Vasilikiotis, M.H. Barnes, M.L. King, J. Org. Chem. 34, 3884 (1969)Google Scholar
  2. 2.
    L.A. Mitscher, W.-N. Wu, R.W. Doscotch, J.L. Beal, Chem. Commun. 589 (1971)Google Scholar
  3. 3.
    W.-N. Wu, J.L. Beal, R.W. Doscotch, Lloydia 40, 508 (1977)Google Scholar
  4. 4.
    K.P. Guha, B. Mukherjee, R. Mukherjee, J. Nat. Prod. 42, 1 (1979)Google Scholar
  5. 5.
    O.N. Tolkachev, E.P. Nakova, R.P. Evstigneeva, Chem. Nat. Comp. 13, 382 (1977)Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

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