Thalicarpine

Reference work entry

CAS Registry Number: 5373-42-2 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Bisisoquinoline Alkaloids

Biological sources: Thalictrum flavum

C41H48N2O8: 696.3411

Mp: 105–106°C (amorph.) [1]; 153–155°C [2]

[α]D +89° (CHCl3) [1]

UV: 282, 303, 316(4.52, 4.38, 4.30) [1]

IR: 2935, 1600, 1505, 1460, 1060, 950 [1]

MSm/z: 696(M+), 490, 324, 293, 206(100), 204 [2]

1H NMR: 2.45, 2.48(each 3H, s, 2 × NCH3), 3.58(3H, s, 7-OCH3), 3.71(3H, s, 1′-OCH3), 3.80, 3.83, 3.91(6H, s, 2 × OCH3, each 3H, s, 2 × OCH3), 3.95(3H, s, 10′-OCH3), 6.21(1H, s, H-8), 6.53, 6.56, 6.60, 6.62(4H, H–Ar), 6.67(1H, H-11) [2]

Abs. conf.: 1R, 6a′S [2]

Pharm./Biol.: LD50 345 mg/kg (i/p, mice). Hypotensive, spasmolytic, anticough action. It inhibits the growth of malignant tumors [3]

References

  1. 1.
    Kh.S. Umarov, Z.F. Ismailov, S.Yu. Yunusov, Chem. Nat. Comp. 6, 452 (1970)Google Scholar
  2. 2.
    H. Guinaudeau, M. Leboeuf, A. Cave, J. Nat. Prod. 42, 133 (1979)Google Scholar
  3. 3.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 250Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

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