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Thalfoetidine (Thalictrinine)

Reference work entry

CAS Registry Number: 16687-93-7 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Bisisoquinoline Alkaloids

Biological sources: Thalictrum longipedunculatum, T. simplex

C38H42N2O7: 638.2992

Mp: 169–170°C (dec.) [1]

[α]D −81° (CHCl3) [1]

Solubility: very sol. CHCl3; spar. sol. Et2O, EtOH, Me2CO [1]

MSm/z: 638(M+, 100), 637(46), 623(9), 607(6), 515(2), 417(63), 402(57), 213(67), 206(18), 190(65), 175(7), 174(5) [2]

1H NMR: 2.32(3H, s, 2-NCH3), 2.72(3H, s, 2′-NCH3), 3.32(3H, s, 7-OCH3), 3.51(3H, s, 7′-OCH3), 3.77(3H, s, 6-OCH3), 3.89(3H, s, 6′-OCH3) [3]

Abs. conf.: 1S, 1′S

Pharm./Biol.: LD50 345 mg/kg (i/p, mice). Antipyretic action [4]

References

  1. 1.
    S.S. Norkina, N.A. Pakhareva, Zh. Obshch. Khim. 20, 1720 (1950)Google Scholar
  2. 2.
    Z.F. Ismailov, S.Yu. Yunusov, Chem. Nat. Comp. 4, 220 (1968)Google Scholar
  3. 3.
    N.M. Mollov, W. Georgiev, Chem. Ind. 27, 1178 (1966)Google Scholar
  4. 4.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 254Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

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