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Thalfine

Reference work entry

CAS Registry Number: 27764-05-2 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Bisisoquinoline Alkaloids

Biological sources: Thalictrum foetidum

C38H36N2O8: 648.2472

Mp: 141–142°C (dec.) [1]

[α]D +69° (EtOH) [1]

UV: 260, 348(4.58, 3.86) [2]

IR: 1562, 1050, 1030, 920 [1, 2]

MSm/z: 648(M+, 100), 647(31), 633(83), 617(21), 442(7), 421(7), 324(49), 220(12), 204(21) [3]

1H NMR: 2.20(3H, s, 2-NCH3), 3.40(3H, s, 7-OCH3), 3.50(3H, s, 6-OCH3), 3.61(3H, s, 5′-OCH3), 3.76(3H, s, 12-OCH3), 5.93(1H, s, H-8), 6.04(2H, s, CH2O2) [2]

Abs. conf.: 1S [4]

Pharm./Biol.: LD50 1,000 mg/kg (i/p, mice). Weak anti-inflammatory and hypothermal action [5]

References

  1. 1.
    S. Abdizhabbarova, Z.F. Ismailov, S.Yu. Yunusov, Chem. Nat. Comp. 4, 281 (1968)Google Scholar
  2. 2.
    S. Abdizhabbarova, Z.F. Ismailov, S.Yu. Yunusov, Chem. Nat. Comp. 6, 281 (1970)Google Scholar
  3. 3.
    W.-T. Liao, J.L. Beal, W.-N. Wu, R.W. Doskotch, Lloydia 41, 257 (1978)Google Scholar
  4. 4.
    G.P. Moiseeva, S.Kh. Maekh, S.Yu. Yunusov, Chem. Nat. Comp. 15, 723 (1979)Google Scholar
  5. 5.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 255Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

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