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Oxyacanthine

Reference work entry

CAS Registry Number: 548-40-3 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Bisisoquinoline Alkaloids

Biological sources: Berberis amurensis, B. crataegina, B. densiflora, B. heteropoda, B. iliensis, B. integerrima, B. nummularia, B. oblonga, B. thunbergii, B. turcomanica, B. vulgaris, Mahonia aquifolia

C37H40N2O6: 608.2886

Mp: 206–208°C (EtOH) [1], 216–217°C (Et2O) [1]

[α]D +279° (CHCl3) [1]

UV: 206, 238 sh, 282(4.94, 5.45, 3.92) [2]

MSm/z: 608(M+), 607, 501, 417, 416, 396, 395, 381, 364, 349, 335, 304(++), 198(++, 100), 192, 175(++), 174 [3]

1H NMR: 2.56(2-NCH3), 2.66(2′-NCH3), 3.18(7′-OCH3), 3.63(H-1, 6-OCH3), 3.79(6′-OCH3), 4.19(H-1′), 5.43(H-10), 6.31(H-5′), 6.34(H-11′), 6.35(H-5), 6.63(H-8), 6.76(H-14), 6.78(H-13), 6.94(H-13′), 6.98(H-10′) [4]

Pharm./Biol.: LD50 43.5 mg/kg (i/v, mice). Hypotensive [6], antimycotic [5], depressive [7] action

References

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    H. Guinaudeau, A.J. Freyer, M. Shamma, Nat. Prod. Rep. 3, 477 (1986)Google Scholar
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    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 82Google Scholar
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    L.P. Naidovich, E.A. Trutneva, O.N. Tolkachev, V.D. Vasil’eva, Farmatsiya 25(4), 33 (1976)Google Scholar
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    O.N. Tolkachev, E.P. Nakova, R.P. Evstigneeva, Chem. Nat. Comp. 13, 382 (1977)Google Scholar

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© Springer Science+Business Media New York 2013

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