Advertisement

Magnolamine

Reference work entry

CAS Registry Number: 573-73-9 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Bisisoquinoline Alkaloids

Biological sources: Magnolia fuscata

C37H42N2O7: 626.299

Mp: 117–118°C (C6H6) [1], 145°C (dec., picrate) [1], 152°C (O,O,O-tri Me) [2]; 103°C (O,O,O- tri Et) [2]

[α]D +183° [2]

Solubility: very sol. EtOH, CHCl3; spar. sol. C6H6

UV: 284(4.11) [3]

IR: 3545, 1650, 1610, 1268, 1220, 1170 [3, 4]

MSm/z: 192(100) [5]

1H NMR: 2.34, 2.43(each 3H, s, 2 × NCH3), 3.74, 3.76, 3.78(each 3H, s, 3 × OCH3), 6.02, 6.21(each 1H, s, H-8, H-8′), 6.73, 6.98(each 2H, d, J = 8, H-10′, H-11′, H-13′, H-14′), 6.46, 6.49(each 1H, s, H-5, H-5′), 6.53, 6.64(each 1H, s, H-11, H-14) [4]

Abs. conf.: 1S, 1′S

Pharm./Biol.: Hypotensive [6] and depressive [7] action

References

  1. 1.
    A.P. Orekhov, N.F. Proskurnina, Zh. Obshch. Khim. 9, 127 (1939)Google Scholar
  2. 2.
    N.F. Proskurnina, A.P. Orekhov, Zh. Obshch. Khim. 16, 129 (1946)Google Scholar
  3. 3.
    J. Holubek, O. Strouf, Spectral Data and Physical Constants of Alkaloids, vol. 4 (Prague Publishing House, Czechoslovak Academy of Sciences/Heyden & Son, London, 1969). No. 558Google Scholar
  4. 4.
    L.D. Yakhontova, O.N. Tolkachev, D.A. Fesenko, Chem. Nat. Comp. 13, 200 (1977)Google Scholar
  5. 5.
    J. Baldas, I.R.C. Bick, T. Ibuka, R.S. Kapil, Q.N. Porter, J. Chem. Soc. Perkin. Trans. 1, 592 (1972)Google Scholar
  6. 6.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 186. M.D. Mashkovskii, In: Main Directions of the Work of VNIKhFI [Sergei Ordzhonikidze All-Union Scientific-Research of Pharmaceutical Chemistry], Moscow, 1959, p. 393Google Scholar
  7. 7.
    O.N. Tolkachev, E.P. Nakova, R.P. Evstigneeva, Chem. Nat. Comp. 13, 382 (1977)Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

Personalised recommendations