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Isotetrandrine

Reference work entry

CAS Registry Number: 518-34-3 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Bisisoquinoline Alkaloids

Biological sources: Berberis crataegina, B. integerrima, B. nummularia, B. thunbergii, B. vulgaris, Mahonia aquifolia

C38H42N2O6: 622.3043

Mp: 181–182°C (Me2CO), 242°C (di methiodide)

[α]D +142° (CHCl3) [1]

UV: 206, 238 sh, 282(4.97, 4.38, 3.85) [2]

MSm/z: 622(M+), 621, 485, 431, 430, 396, 395, 381, 364, 349, 198(++), 190, 175(++), 174 [3]

1H NMR: 2.26(3H, s, 2-NCH3), 2.57(3H, s, 2′-NCH3), 3.13(3H, s, 7-OCH3), 3.62(3H, s, 6′-OCH3), 3.76(3H, s, 6-OCH3), 3.82(H-1), 3.84(H-1′), 3.92(3H, s, 12-OCH3), 5.99(H-8′), 6.28(H-5), 6.42(H-10, H-10′), 6.54(H-5′), 6.65(H-11′), 6.78(H-14), 6.80(H-13), 7.10(H-13′), 7.27(H-14′) [4]

Pharm./Biol.: Antituberculous activity [5]

References

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    R. Shakirov, M.V. Telezhenetskaya, I.A. Bessonova, S.F. Aripova, I.A. Israilov, M.N. Sultankhodzhaev, V.I. Akhmedzhanova, V.I. Vinogradova, T.S. Tulyaganov, B.T. Salimov, V.A. Tel’nov, Chem. Nat. comp. 32, 386 (1996)Google Scholar
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    A.R. Battersby, I.R.C. Bick, W. Klyne, J.P. Jennings, P.M. Scopes, M.J. Vernengo, J. Chem. Soc. 2239 (1965)Google Scholar
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    J. Baldas, I.R.C. Bick, T. Ibuka, R.S. Kapil, Q.N. Porter, J. Chem. Soc. Perkin. Trans. 1, 592 (1972)Google Scholar
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    H. Cuinaudeau, A.J. Freyer, M. Shamma, Nat. Prod. Rep. 5, 477 (1986)Google Scholar
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    O.N. Tolkachev, Chem. Nat. Comp. 17, 263 (1981)Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

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