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Hernandezine (Thalicsimine)

Reference work entry

CAS Registry Number: 6681-13-6 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Bisisoquinoline Alkaloids

Biological sources: Thalictrum alpinum, T. simplex, T. sultanabadense

C39H44N2O7: 652.3148

Mp: 153–154°C (EtOH) [1], 122–123°C (Me2CO) [2], 190–193°C [3], 211°C (dec., nitrate), 253°C (hydrobromide), 242°C (hydroiodide), 236°C ([dec.] methiodide) [1], 192°C (α-des. [α]D 0°) [4], 230° (dec., hydrochloride) [5], 204° (dec., picrate), 152° (β-des. [α]D +422° [CHCl3]) [5]

[α]D +221° (CHCl3) [1], +250° (CHCl3) [3]

Solibility: very sol. Me2CO, MeOH, EtOH, Et2O, C6H6, CHCl3; spar. sol. pet. ether; insol. H2O, alk. [1]

UV: 286(3.76) [2]

IR: [3]

MSm/z: 652(M+, 62), 651(31), 637(12), 461(16), 426(17), 425, 411, 394, 379, 365, 213(++, 100), 192, 190(++, 13), 174(27) [6, 7, 8]

1H NMR: 2.24(3H, s, 2-NCH3), 2.55(3H, s, 2′-NCH3), 3.18(3H, s, 7-OCH3), 3.27(3H, s, 6′-OCH3), 3.73(3H, s, 6-OCH3), 3.75(3H, s, 5-OCH3), 3.85(3H, s, 12-OCH3), 5.92(1H, s,...

References

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© Springer Science+Business Media New York 2013

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