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Fetidine

Reference work entry

CAS Registry Number: 7072-86-8 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Bisisoquinoline Alkaloids

Biological sources: Thalictrum foetidum

C40H46N2O8: 682.3254

Mp: 132–135°C (EtOAc) [1], 200°C (dec., nitrate), 230°C (dec., hydrochloride), 230°C (hydrobromide), 218°C (dec., sulfate), 210°C (methiodide)

[α]D +121° (MeOH) [1]

UV: 220, 280, 305(4.80, 4.36, 4.24) [2]

IR: 3400, 2830, 2800, 1605, 1580, 1515 [2]

MSm/z: 476(1.5), 341(++, 3), 327(5), 284(3), 206(100), 191(10) [3]

1H NMR: 2.30, 2.37(each 3H, s, 2 × NCH3), 3.50(3H, s, 7′-OCH3), 3.71, 3.78, 3.81(6H, 3H, 3H, s, 4 × OCH3), 3.90(3H, s, 10-OCH3), 6.14(1H, s), 6.42(1H, s), 6.52(2H, s), 6.75, 6.81(each 1H, d, J = 8.5), 8.12(1H, s, H-11) [4]

Abs. conf.: 1′R, 6a S [5]

CD: [5]

Pharm./Biol.: Anti-inflammatory, hypotensive activity [6]. Inhibitory influence on the higher nervous activity [7]

References

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    Z.F. Ismailov, S.Yu. Yunusov, Chem. Nat. Comp. 2, 35 (1966)Google Scholar
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    Z.F. Ismailov, S.Yu. Yunusov, Chem. Nat. Comp. 142 (1970)Google Scholar
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    Z.F. Ismailov, M.R. Yagudaev, S.Yu. Yunusov, Chem. Nat. Comp. 4, 226 (1968). M.P. Cava, K. Wakisaka, Tetrahedron Lett. 13, 2309 (1972)Google Scholar
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    G.P. Moiseeva, Z.F. Ismailov, S.Yu. Yunusov, Chem. Nat. Comp. 6, 715 (1970)Google Scholar
  6. 6.
    F. Sadritdinov, Farmakologiya alkaloidov i ikh proizvodnykh (Fan, Tashkent, 1972), p. 154Google Scholar
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    I. Khamdamov, F. Sadritdinov, M.B. Sultanov, Farmakologiya alkaloidov i serdechnykh glikozidov (Fan, Tashkent, 1971), p. 135Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

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