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Aporphine Alkaloids

Reference work entry

Aporphine alkaloids form a large group of isoquinoline alkaloids that number more than 700 compounds. This section includes data on 90 aporphine alkaloids isolated from plants growing in the CIS. Plants of the families Berberidaceae, Fumariaceae, Magnoliaceae, Papaveraceae, Ranunculaceae, and others are rich in these alkaloids.

Aporphine alkaloids have a biphenyl system and can be di-, tri-, tetra-, penta-, and hexa-substituted derivatives where the substituents are hydroxyl, methoxyl, and methylenedioxy that can be situated over all four rings. The most widely distributed in nature are 1,2,9,10- and 1,2,10,11-tetrasubstituted bases and 1,2,3,9,10-pentasubstituted ones. The disubstituted aporphines have substituents in the 1- and 2-positions. N-oxides of aporphine alkaloids have also been isolated. The N atom in aporphines can be secondary, tertiary, and quaternary.

Oxoaporphine alkaloids with a completely dehydrogenated system and a C-7 ketone are widely distributed. These optically...

References

  1. S.Yu. Yunusov, Izv. Akad. Nauk Uzb. SSR (4), 11 (1948)Google Scholar

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