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Robustine

Reference work entry

CAS Registry Number: 2255-50-7 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Quinoline Alkaloids

Biological sources: Dictamnus caucasicus, Haplophyllum bucharicum, H. dauricum, H. dubium, H. obtusifolium, H. pedicellatum, H. perforatum, H. ramosissimum, H. robustum

C12H9NO3: 215.0582

Mp: 147–149°C (EtOH), 200°C (hydrochloride), 180°C (picrate), 175°C (Ac), 202°C (tetrahydro), 141°C (O–Me) [1]

Solubility: very sol. Me2CO, CHCl3; spar. sol. EtOH; insol. H2O [1]

UV: 246, 314, 330, 342 (4.86, 3.94, 3.94, 3.92) [1]

IR: 3300, 3130, 1622, 1590, 1528, 1368, 1310, 1190, 1108, 1060, 1000 [1, 2]

MSm/z: 215(M+, 100), 200(44), 186(26), 172(26), 144(14), 116(14), 83(12), 63(5) [3]

1H NMR: 4.30(3H, s, OCH3), 6.91, 7.47(each 1H, d, J = 3, H-3, H-2), 7.10(2H, m, H-6, H-7), 7.59(1H, dd, J = 9, 2.5, H-5) [2]

Pharm./Biol.: LD50 300 mg/kg (oral, mice) [4, 5]

References

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    I.M. Fakhrutdinova, G.P. Sidyakin, S.Yu. Yunusov, Chem. Nat. Comp. 1, 83 (1965)Google Scholar
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    R. Shakirov, M.V. Telezhenetskaya, I.A. Bessonova, S.F. Aripova, I.A. Israilov, M.N. Sultankhodzhaev, V.I. Vinogradova, V.I. Akhmedzhanova, T.S. Tulyaganov, B.T. Salimov, V.A. Tel’nov, Chem. Nat. Comp. 32, 737 (1996)Google Scholar
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    Z.Sh. Faizutdinova, S.Yu. Yunusov, Chem. Nat. Comp. 3, 218 (1967)Google Scholar
  4. 4.
    M.B. Sultanov, The Pharmacology of Plant Substances [in Russian] (FAN, Tashkent, 1976), p. 3Google Scholar
  5. 5.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 272Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

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