Advertisement

Perforine

Reference work entry

CAS Registry Number: 18063-20-2 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Quinoline Alkaloids

Biological sources: Haplophyllum perforatum

C18H25NO5: 335.1733

Mp: 182–183°C (MeOH), 158°C (chlor. Ac), 144°C (EtOH., anhydro.), 107°C (tetrahydro), 169°C (dihydro) [1]

[α]D +15° (MeOH) [1]

Solubility: sol. DMSO.; spar. sol. CHCl3, MeOH, Me2CO; insol. Et2O, pet. ether, H2O [2]

UV: 256 (4.00) [1]

IR: 3420, 3148, 3118, 1605, 1585, 1545, 1475, 1267, 1100 [2]

MSm/z: 335(M+, 62), 302(74), 288(31), 270(10), 248(34), 228(26), 216(100), 202(31), 201(30), 188(87), 173(8) [2]

1H NMR: 1.20, 1.24(each 3H, s, 2 × CH3), 3.09, 4.19(each 3H, s, 2 × OCH3), 4.20(1H, m, H-7), 6.87, 7.47(each 1H, J = 3, H-3, H-2) [2]

13 C NMR(DMSO-d 6): [ 3]

Table 1

C-2

142.7

C-5

18.0

C-10

23.2

 2a

161.9

 6

23.9

 11

69.2

 3

104.6

 7

67.2

 12

29.4

 3a

116.5

 8

78.0

 13

29.4

 4

157.9

 8a

151.2

4-OCH3

58.6

 4a

104.9

 9

35.9

8-OCH3

49.6

References

  1. 1.
    Z.Sh. Faizutdinova, I.A. Bessonova, S.Yu. Yunusov, Chem. Nat. Comp. 4, 304 (1968)Google Scholar
  2. 2.
    I.A. Bessonova, Z.Sh. Faizutdinova, Ya.V. Rashkes, M.R. Yagudaev, S.Yu. Yunusov, Chem. Nat. Comp. 5, 231 (1969); R. Shakirov, M.V. Telezhenetskaya, I.A. Bessonova, S.F. Aripova, I.A. Israilov, M.N. Sultankhodzhaev, V.I. Vinogradova, V.I. Akhmedzhanova, T.S. Tulyaganov, B.T. Salimov, V.A. Tel’nov, Chem. Nat. Comp. 32, 737 (1996)Google Scholar
  3. 3.
    M.R. Yagudaev, I.A. Bessonova, Chem. Nat. Comp. 25, 20 (1989)Google Scholar
  4. 4.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 275Google Scholar
  5. 5.
    Kh.S. Akhmedkhodjaeva, The Pharmacology of Natural Substances [in Russian] (FAN, Tashkent, 1978), p. 51Google Scholar
  6. 6.
    S.S. Nazrullaev, I.A. Bessonova, Kh.S. Akhmedkhodjaeva, Chem. Nat. Comp. 37, 551 (2001)Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

Personalised recommendations