Haplophidine (Haplophydine)

Reference work entry

CAS Registry Number: 55727-61-2 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Quinoline Alkaloids

Biological sources: Haplophyllum perforatum

C17H17NO3: 283.1208

Mp: 111–112°C (Et2O) [1]

Solubility: very sol. CHCl3, Me2CO; sol. EtOH, Et2O; insol. H2O [1]

UV: 245, 261 sh, 272 sh, 300 sh, 314, 329, 342 (4.82, 3.96, 3.72, 3.75, 3.84, 3.80, 3.75) [1]

IR: 3160, 3140, 1625, 1590, 1525, 1450, 1400, 1370, 1302, 1275, 1193, 1160, 1100, 1070, 990 [1, 2]

MSm/z: 283(M+, 6), 215(100), 200(23), 186(7), 172(7), 156(5), 69(5) [1]

1H NMR: 1.78(6H, s, 2 × CH3), 4.32(3H, s, OCH3), 4.75, 5.58(2H, d, 1H, t, J = 6.5, O–CH2–CH), 6.95, 7.53(each 1H, d, J = 3, H-3, H-2), 6.98, 7.23, 7.72(each 1H, q, t, q, J = 8, 1.5, H-7, H-6, H-5) [1]

References

  1. 1.
    Kh.A. Abdullaeva, I.A. Bessonova, S.Yu. Yunusov, Chem. Nat. Comp. 10, 713 (1974)Google Scholar
  2. 2.
    R. Shakirov, M.V. Telezhenetskaya, I.A. Bessonova, S.F. Aripova, I.A. Israilov, M.N. Sultankhodzhaev, V.I. Vinogradova, V.I. Akhmedzhanova, T.S. Tulyaganov, B.T. Salimov, V.A. Tel’nov, Chem. Nat. Comp. 32, 932 (1996)Google Scholar

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