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Dubamine

Reference work entry

CAS Registry Number: 6808-65-7 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Quinoline Alkaloids

Biological sources: Dictamnus angustifolius, Haplophyllum dubium, H. latifolium

C16H11NO2: 249.0790

Mp: 96–97°C (pet. ether.), 202°C (hydrochloride), 158°C (nitrate), 187°C (oxalate) [1]

UV: 222 sh, 237 sh, 336, 374 sh (4.55, 4.36, 4.12, 3.64) [2]

IR: 1610, 1500, 1445, 1400, 1360, 1098, 1050, 935 [2]

MSm/z: 249(M+, 100), 248(62), 220(10), 192(20), 191(43), 164, 163, 128, 101 [3]

1H NMR(CF3COOH): 5.72(2H, s, OCH2O), 6.68(1H, d, J = 7.5, H-5′), 7.02(1H, d, J = 1.5, H-2′), 7.20(1H, dd, J = 7.5, 1.5, H-6′), 7.80(5H, m, H–Ar), 8.08(1H, d, J = 8, H-4) [2]

Pharm./Biol.: 2500 mg/kg does not cause the death of mice. 50 mg/kg briefly and slightly lowers the arterial pressure and increases the rate of respiration in narcotized dogs [4]

References

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    G.P. Sidyakin, I.A. Bessonova, V.I. Pastukhova, S.Yu. Yunusov, Zh. Obshch. Khim. 32, 4091 (1962)Google Scholar
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    R. Shakirov, M.V. Telezhenetskaya, I.A. Bessonova, S.F. Aripova, I.A. Israilov, M.N. Sultankhodzhaev, V.I. Vinogradova, V.I. Akhmedzhanova, T.S. Tulyaganov, B.T. Salimov, V.A. Tel’nov, Chem. Nat. Comp. 32, 386 (1996)Google Scholar
  3. 3.
    Z.Sh. Faizutdinova, S.Yu. Yunusov, Chem. Nat. Comp. 3, 218 (1967)Google Scholar
  4. 4.
    M.B. Sultanov, The Pharmacology of Plant Substances [in Russian] (FAN, Tashkent, 1976), p. 3Google Scholar

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© Springer Science+Business Media New York 2013

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