Licorice-Saponin H2

Reference work entry

CAS Registry Number: 135815-61-1 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Triterpene Glycosides – Glycosides of Aglycones of Oleanene Type – Liquiritic Acid

Biological source: Glycyrrhiza uralensis [1, 2], G. inflata [3]

C42H62O16: 822.403

Mp: 209–210°C [2]

[α]D25 + 31° (c 0.21, MeOH) [2]

IR (KBr) νmax cm−1: 3500-3300, 2920, 1725, 1645, 1386, 1200, 1040 [2]

UV λmaxMeOH nm (ε): 248 (10700) [1]

FAB-MSm/z: 861 (M + K)+, 845 (M + Na)+ [1]

FAB-MS (positive ion mode) m/z: 823 [(M + H)+], 647 [(M + H)-GlcUA]+, 471 [(647-GlcUA)+], 453 [(471-H2O)+] [2]

FAB-MS (negative ion mode) m/z: 821 [(M-H)], 645 [(M-H)-GlcUA], 469 [(M-H-2GlcUA)−] [2]

1H NMR (500 MHz, J/Hz, C5D5N): 0.87, 1.06, 1.19, 1.20, 1.35, 1.36, 1.38 (s, CH3 × 7), 3.00 (brd, J = 13.0, H-18), 3.35 (dd, J = 4.0, 10.2, H-3), 5.79 (brs, H-12), 4.97 (d, J = 7.6, H-1 of GlcUA), 5.35 (d, J = 7.6, H-1 of GlcUA′) [2]

13 C NMR (22.5 MHz, C 5D 5N) (for methyl derivate): [ 1]

Table 1

C-3

89.2

GlcUA-1

104.9

References

  1. 1.
    I. Kitagawa, J.L. Zhou, M. Sakagami, E. Uchida, M. Yoshikawa, Chem. Pharm. Bull. 39(1), 244 (1991)CrossRefGoogle Scholar
  2. 2.
    I. Kitagawa, K. Hori, M. Sakagami, J.L. Zhou, M. Yoshikawa, Chem. Pharm. Bull. 41(8), 1337 (1993)CrossRefGoogle Scholar
  3. 3.
    I. Kitagawa, K. Hori, M. Sakagami, F. Hashiuchi, M. Yoshikawa, J. Ren, Chem. Pharm. Bull. 41(8), 1350 (1993)CrossRefGoogle Scholar

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© Springer Science+Business Media New York 2013

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