Neuroprotection Strategies During Cardiopulmonary Bypass

Reference work entry


The conduct of operative procedures for repair of congenital cardiac defects has evolved over time. Initially, intracardiac operations were performed with the aid of profound hypothermia and circulatory arrest. Over time, bypass and surgical techniques improved, obviating the need for deep hypothermic circulatory arrest for all but the most complex surgical procedures. Since the beginning, congenital cardiac diseases and the surgical intervention for these defects have been associated with neurologic dysfunction. The perioperative period has often been associated with the complication of neurologic injury, although it has become quite clear that the perioperative period is only one small point in time in which neurologic injury can occur. However, several important variables and techniques used for the management of congenital cardiac defects may help prevent neurologic injury. This chapter overviews some of the strategies utilized for neuroprotection.


Circulatory Arrest Hypoplastic Left Heart Syndrome Arterial Switch Operation Deep Hypothermic Circulatory Arrest Selective Cerebral Perfusion 
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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Pediatric Cardiothoracic SurgeryWake Forest Baptist Health/Brenner Children’s HospitalWinston-SalemUSA
  2. 2.Pediatric Cardiac SurgeryWake Forest UniversityWinston-SalemUSA

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