Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Major Histocompatibility Complex (MHC), Binder Prediction

  • Yasser EL-Manzalawy
  • Vasant Honavar
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_97



Major histocompatibility complex (MHC) binders are short linear fragments of proteins that bind to MHC molecules for inspection by T-cell receptors (TCRs). T-cells recognize non-self antigens as peptide fragments bounded to MHC molecules and presented in the surface of the cell. MHC molecules are membrane proteins whose outer extracellular domains form a cleft in which a peptide fragment is bound. There are two major types of MHC molecules: (1) MHC class I (MHC-I) molecules that bind intracellular short peptides, derived from the degradation of ubiquitinated cytosolic proteins in proteasomes, and present them to the cell surface for recognition by T-cells with CD8 receptors; (2) MHC class II (MHC-II) molecules that bind extracellular peptides and present them to the cell surface for recognition by T-cells with CD4 receptors.

A major difference between MHC-I and MHC-II binders has to do with...

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Center for Computational Intelligence, Learning, and DiscoveryComputer Science, Iowa State UniversityAmesUSA