Definition
Major histocompatibility complex (MHC) binders are short linear fragments of proteins that bind to MHC molecules for inspection by T-cell receptors (TCRs). T-cells recognize non-self antigens as peptide fragments bounded to MHC molecules and presented in the surface of the cell. MHC molecules are membrane proteins whose outer extracellular domains form a cleft in which a peptide fragment is bound. There are two major types of MHC molecules: (1) MHC class I (MHC-I) molecules that bind intracellular short peptides, derived from the degradation of ubiquitinated cytosolic proteins in proteasomes, and present them to the cell surface for recognition by T-cells with CD8 receptors; (2) MHC class II (MHC-II) molecules that bind extracellular peptides and present them to the cell surface for recognition by T-cells with CD4 receptors.
A major difference between MHC-I and MHC-II binders has to do with the...
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EL-Manzalawy, Y., Honavar, V. (2013). Major Histocompatibility Complex (MHC), Binder Prediction. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_97
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