Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Protein Structure Comparison, High-Performance Computing

  • Matteo Comin
  • Concettina Guerra
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_968



Research in biological and medical areas (also known as biomedicine) requires high-performance computing power and sophisticated software tools to treat the huge amount of data derived by ever more accurate experiments in biomedicine. The emerging bioinformatics area involves an increasing number of computer scientists studying new algorithms and designing powerful computational platforms to bring computer science in biomedical research.

Among the different topics, bioinformatics focuses on the study of proteins and their biological functions. Proteins are sequences of amino acids, represented by strings. Amino acids sequences fold in three dimensional (3D) space assuming a variety of 3D structures. Since the structure of a protein is highly related to its functionality, knowing the amino acids sequence as well as its 3D space conformation helps biologists in predicting protein functionalities. The high...

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Department Information EngineeringUniversity of PadovaPadovaItaly