Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Phylogenetic and Ancestral Reconstruction of Multichromosomal Genomes

  • Jijun Tang
  • David A. Bader
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_967


Phylogeny: A Phylogeny is an evolutionary tree reconstructed from its leaves (each of which represents a different species) by using DNA sequence or gene data and a plausible model of evolution. Because phylogenies are crucial to answering many fundamental open questions in biomolecular evolution, biologists have a strong interest in algorithms that enable resolution of ancient relationships. A considerable body of applied research depends on these algorithms, as well. Pharmaceutical companies use phylogenetic analysis in drug discovery – for instance, in discovering biochemical pathways unique to target organisms. Health organizations study the phylogenies of organisms such as HIV to understand their epidemiologies and to aid in predicting the course of disease of time within an individual. Government laboratories work to develop improved strains of basic foodstuffs, such as rice, wheat, and potatoes using an understanding of the phylogenetic distribution of variation in...

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Department of Computer Science and EngineeringUniversity of South CarolinaColumbiaUSA
  2. 2.School of Computational Science and Engineering, College of ComputingGeorgia Institute of TechnologyAtlantaUSA