Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Protein-Protein Interaction Networks

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_878

Synonyms

Definition

A protein-protein interaction (PPI) network is a network or graph representation of physical interactions between protein pairs in an organism. In the network, each node/vertex represents a protein and each edge/link represents an interaction. The network is undirected, usually simple (which means maximally only one edge is allowed between two proteins), and allows self-loops (which indicates interactions between the same protein). PPIs can be determined by small- or large-scale experiments such as the yeast-two-hybrid screens or tandem affinity purification experiments, computational predictions such as interolog mapping, multimeric threading or machine learning, and expert curations (Xia et al. 2004).

Cross-References

References

  1. Xia Y, Yu H, Jansen R, Seringhaus M, Baxter S et al (2004) Analyzing cellular biochemistry in terms of molecular networks. Annu Rev Biochem 73:1051–1087PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Division of Biomedical InformaticsCincinnati Children’s Hospital Research FoundationCincinnatiUSA
  2. 2.Department of Computer ScienceUniversity of CincinnatiCincinnatiUSA