Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Pharmacogenomics

  • Vani Brahmachari
  • Shruti Jain
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_861

Synonyms

Definition

Pharmacogenomics aims at studying the variations in drug metabolism pathways at the genome level and utilizes this information for new drug discovery and to optimize the existing drug therapies (Weinshilboum and Wang 2004). In the “omics” era, the advent of personalized medicine has its roots in these variations; and hence, the need to optimize the drugs according to the genotype of an individual to ensure the best drug response with minimal adverse effects (Roden and George2002). The concept of using whole-genome information to predict drug action is called “pharmacogenomics.”

Pharmacogenetics refers to the genetic variations in drug metabolism pathways that affect an individual’s response to a drug, whereas pharmacogenomics encompasses the epigenetic as well as genetic variations in these pathways.

Cross-References

References

  1. Roden DM, George AL Jr (2002) The genetic basis of variability in drug responses. Nat Rev Drug Discov 1:37–44PubMedGoogle Scholar
  2. Weinshilboum R, Wang L (2004) Pharmacogenomics: bench to bedside. Nat Rev Drug Discov 3:739–748PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Dr. B. R. Ambedkar Center for Biomedical Research, University of DelhiDelhiIndia