Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Post-Replication Modification

  • Vani Brahmachari
  • Shruti Jain
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_855



The post-replication modifications are conferred on newly synthesized DNA while being packaged into  chromatin. They include the methylation of cytosine residues on hemi-methylated DNA and also de novo methylation. The marking of histone tails with post-translational modifications like acetylation, methylation, phosphorylation, and ubiqutination ( Ubiquitin and SUMO) and also the insertion of histone variants like H2A.Z, macroH2A, H2A.X or H3.1, H3.2, and H3.3 into  nucleosomes are also carried out after replication.


Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Dr. B. R. Ambedkar Center for Biomedical Research, University of DelhiDelhiIndia