Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Pharmacokinetics and Pharmacodynamics

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_843

Synonyms

Definition

Pharmacokinetics can be defined as an individual’s response to drug administered (Weinshilboum and Wang 2004). It includes the study of the mechanisms of absorption, action, and excretion of an administered drug. The rate of absorption of drug and the duration of the effect, the chemical changes brought about on the drug molecule in the body, and the rate and routes of excretion of the metabolites of the drug are dynamic parameters studied under pharmacokinetics. These parameters determine the effective concentration of the drug available for action at the target site – referred to as bioavailability. Pharmacokinetics describes the relationship between the drug dose and the resulting drug concentrations in plasma and tissue. It is influenced by variations in drug transport and metabolism (Fig.  1).
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References

  1. Roden DM, George AL Jr (2002) The genetic basis of variability in drug responses. Nat Rev Drug Discov 1:37–44PubMedGoogle Scholar
  2. Weinshilboum R, Wang L (2004) Pharmacogenomics: bench to bedside. Nat Rev Drug Discov 3:739–748PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Dr. B. R. Ambedkar Center for Biomedical ResearchUniversity of DelhiDelhiIndia