Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Interacting Cell Systems

  • Anja Voss-Böhme
  • Andreas Deutsch
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_839



An interacting cell system (ICS) is a spatial modeling framework that allows to analyze the collective spatio-temporal behavior ( Collective Behavior,  Spatiotemporal Pattern Formation) of biological cell populations which emerges from local intercellular interactions. The model is a systems biology adaption of interacting particle systems (IPS) which have been used in nonequilibrium statistical physics. Mathematically, ICSs refer to a class of stochastic processes, more specific Markov processes ( Markov Chain), in which time is continuous and space is discretized, the latter resembled by a regular lattice or a more general graph structure (Liggett 1985). Each spatial location can be in one of a discrete number of states – interpreted, for instance, as the state or type of a cell at that location. The dynamics is described by specifying the transition rules for changing a configuration of cells within small subregions....

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Anja Voss-Böhme
    • 1
  • Andreas Deutsch
    • 1
  1. 1.Center for Information Services and High Performance Computing (ZIH), Technical University DresdenDresdenGermany