Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Pro-Inflammatory Mediators

  • Christian Schönbach
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_747



Pro-inflammatory mediators comprise antiviral interferons (e.g., INFA1 and INFB1), cytokines (e.g., TNFA1, IL1B, IL6 and IL12), and chemokines such as IL8, which are activated by transcription factor NFKB1 (Delves et al. 2006). Pro-inflammatory mediators are produced by macrophages and various mesenchymal cells, for example, endothelial and epithelial cells.



  1. Delves P, Martin S, Burton D, Roitt I (2006) Roitt’s essential immunology, 11th edn. Wiley-Blackwell, Malden, pp 6–7Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Department of Bioscience and BioinformaticsKyushu Institute of TechnologyIizukaJapan