Pro-inflammatory mediators comprise antiviral interferons (e.g., INFA1 and INFB1), cytokines (e.g., TNFA1, IL1B, IL6 and IL12), and chemokines such as IL8, which are activated by transcription factor NFKB1 (Delves et al. 2006). Pro-inflammatory mediators are produced by macrophages and various mesenchymal cells, for example, endothelial and epithelial cells.
- Delves P, Martin S, Burton D, Roitt I (2006) Roitt’s essential immunology, 11th edn. Wiley-Blackwell, Malden, pp 6–7Google Scholar