Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Warburg Effect

  • Kareenhalli V. Venkatesh
  • Lalit Darunte
  • P. Jayadeva Bhat
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_703

Synonyms

Definition

Warburg effect is a phenomenon predominantly observed in cancer cells wherein cells ferment glucose to lactic acid using glycolysis even in the presence of oxygen. Otto Warburg observed this effect in 1926 and postulated it to be the fundamental cause of cancer (Fig. 1).
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References

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  6. Vander Heiden MG, Cantley LC et al (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324(5930):1029–1033CrossRefGoogle Scholar
  7. Warburg O (1956) On the origin of cancer cells. Science 123(3191):309–314PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Kareenhalli V. Venkatesh
    • 1
  • Lalit Darunte
    • 1
  • P. Jayadeva Bhat
    • 2
  1. 1.Department of Chemical EngineeringIndian Institute of TechnologyMumbai, MaharashtraIndia
  2. 2.School of Bioscience and EngineeringIndian Institute of TechnologyMumbaiIndia