Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota


  • Jean Clairambault
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_696


Pharmacokinetics-pharmacodynamics (PK-PD) (Macheras and Iliadis 2006) is the discipline that associates the representation of the fate of a drug in a living organism, from its infusion in the circulation or absorption by oral route until it reaches its cell target, with the representation of the effects of its action on its target. The first part (journey of the drug) is the object of pharmacokinetics, the second (drug effects) of pharmacodynamics. Pharmacokinetics may use in a plain descriptive way curves representing the time evolution of drug concentrations in the media it visits by purely descriptive parameters, or by dynamical systems admitting such curves as their trajectories. In the same way, pharmacodynamics may use from a macroscopic viewpoint measurable effects, such as variations of blood pressure, as a function of the drug dose, either instantaneously or daily, or at the molecular level, chemical reaction equations that are at the core of the effective...

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  1. Macheras P, Iliadis A (2006) Modeling in biopharmaceutics, pharmacokinetics and pharmacodynamics: homogeneous and heterogeneous approaches. Springer, New YorkGoogle Scholar
  2. Tozer TN, Rowland M (2006) Introduction to pharmacokinetics and pharmacodynamics: the quantitative basis of drug therapy. Lippincott, BaltimoreGoogle Scholar

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Equipe-Projet BANGINRIA Paris-Rocquencourt BP 105Le Chesnay, ParisFrance