Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota


  • Marie-Paule LefrancEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_674


Productive” is a  leafconcept of the “ FunctionalityType” concept of identification (generated from the  IDENTIFICATION Axiom) of  IMGT-ONTOLOGY, the global reference in  immunogenetics and  immunoinformatics (Giudicelli and Lefranc 1999; Lefranc et al. 2004, 2005, 2008; Duroux et al. 2008), built by IMGT®, the international ImMunoGeneTics information system® (http://www.imgt.org) ( IMGT® Information System). “Productive” identifies, whatever the molecule type ( MoleculeType), the functionality of  Molecule_EntityType leafconcepts in rearranged or partially-rearranged configuration ( Configuration Type), whose coding region has an open reading frame without stop codon, whose junction is in-frame (for immunoglobulin (IG) and T cell receptor (TR)) and for which there is no described defect in the initiation codon, splicing sites, and/or regulatory elements.

“Productive” is one of the two leafconcepts (the other one being “ Unproductive”) that identify the functionality of “ Molecule_EntityType...

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Laboratoire d’ImmunoGénétique Moléculaire, Institut de Génétique Humaine UPR 1142, Université Montpellier 2MontpellierFrance