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Definition
Paratope is a concept of the SpecificityType concept of identification (generated from the IDENTIFICATION Axiom), of IMGT-ONTOLOGY, the global reference in immunogenetics and immunoinformatics (Giudicelli and Lefranc 1999; Lefranc et al. 2004, 2005, 2008; Duroux et al. 2008), built by IMGT®, the international ImMunoGeneTics information system® (http://www.imgt.org) (IMGT® Information System). Paratope, or “antigen-binding site,” identifies the part of the variable (V) domains (Variable (V) Domain) of an immunoglobulin (IG) or antibody or of a T cell receptor (TR) that, respectively, recognizes (binds to) the antigen (Ag) or the peptide/major histocompatibility (pMH) (“Epitope” or “antigenic determinant”).
The “Paratope” concept has two leafconcepts (IMGT-ONTOLOGY, Leafconcept):
The ‘IG or antibody paratope’ identifies the part of the IG or antibody that recognizes a B cell epitope (part of an Ag)
The ‘TR paratope’ identifies the part of the TR...
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References
Duroux P, Kaas Q, Brochet X, Lane J, Ginestoux C, Lefranc M-P, Giudicelli V (2008) IMGT-Kaleidoscope, the Formal IMGT-ONTOLOGY paradigm. Biochimie 90:570–583
Giudicelli V, Lefranc M-P (1999) Ontology for immunogenetics: the IMGT-ONTOLOGY. Bioinformatics 12:1047–1054
Kaas Q, Duprat E, Tourneur G. Lefranc M-P (2008) IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes. In: Schoenbach C, Ranganathan S, Brusic V (eds) Immunoinformatics. Immunomics reviews, series of Springer Science and Business Media LLC. Springer, New York, USA, Chap. 2, pp19–49
Lefranc M-P, Giudicelli V, Ginestoux C, Bose N, Folch G, Guiraudou D, Jabado-Michaloud J, Magris S, Scaviner D, Thouvenin V, Combres K, Girod D, Jeanjean S, Protat C, Yousfi Monod M, Duprat E, Kaas Q, Pommié C, Chaume D, Lefranc G (2004) IMGT-ONTOLOGY for immunogenetics and immunoinformatics. In Silico Biol 4:17–29
Lefranc M-P, Clément O, Kaas Q, Duprat E, Chastellan P, Coelho I, Combres K, Ginestoux C, Giudicelli V, Chaume D, Lefranc G (2005) IMGT-Choreography for immunogenetics and immunoinformatics. In Silico Biol 5:45–60
Lefranc M-P, Giudicelli V, Regnier L, Duroux P (2008) IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics. Brief Bioinform 9:263–275
Pommié C, Levadoux S, Sabatier R, Lefranc G, Lefranc M-P (2004) IMGT standardized criteria for statistical analysis of immunoglobulin V-REGION amino acid properties. J Mol Recognit 17:17–32
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Lefranc, MP. (2013). Paratope. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_673
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_673
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