Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Paratope

  • Marie-Paule Lefranc
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_673

Synonyms

Definition

Paratope is a concept of the  SpecificityType concept of identification (generated from the  IDENTIFICATION Axiom), of  IMGT-ONTOLOGY, the global reference in  immunogenetics and  immunoinformatics (Giudicelli and Lefranc 1999; Lefranc et al. 2004, 2005, 2008; Duroux et al. 2008), built by IMGT®, the international ImMunoGeneTics information system® (http://www.imgt.org) ( IMGT® Information System). Paratope, or “antigen-binding site,” identifies the part of the variable (V) domains ( Variable (V) Domain) of an immunoglobulin (IG) or antibody or of a T cell receptor (TR) that, respectively, recognizes (binds to) the antigen (Ag) or the peptide/major histocompatibility (pMH) (“ Epitope” or “antigenic determinant”).

The “Paratope” concept has two leafconcepts (  IMGT-ONTOLOGY, Leafconcept):
  • The ‘IG or antibody paratope’ identifies the part of the IG or antibody that recognizes a B cell epitope (part of an Ag)

  • The ‘TR paratope’ identifies the part...

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References

  1. Duroux P, Kaas Q, Brochet X, Lane J, Ginestoux C, Lefranc M-P, Giudicelli V (2008) IMGT-Kaleidoscope, the Formal IMGT-ONTOLOGY paradigm. Biochimie 90:570–583PubMedGoogle Scholar
  2. Giudicelli V, Lefranc M-P (1999) Ontology for immunogenetics: the IMGT-ONTOLOGY. Bioinformatics 12:1047–1054Google Scholar
  3. Kaas Q, Duprat E, Tourneur G. Lefranc M-P (2008) IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes. In: Schoenbach C, Ranganathan S, Brusic V (eds) Immunoinformatics. Immunomics reviews, series of Springer Science and Business Media LLC. Springer, New York, USA, Chap. 2, pp19–49Google Scholar
  4. Lefranc M-P, Giudicelli V, Ginestoux C, Bose N, Folch G, Guiraudou D, Jabado-Michaloud J, Magris S, Scaviner D, Thouvenin V, Combres K, Girod D, Jeanjean S, Protat C, Yousfi Monod M, Duprat E, Kaas Q, Pommié C, Chaume D, Lefranc G (2004) IMGT-ONTOLOGY for immunogenetics and immunoinformatics. In Silico Biol 4:17–29PubMedGoogle Scholar
  5. Lefranc M-P, Clément O, Kaas Q, Duprat E, Chastellan P, Coelho I, Combres K, Ginestoux C, Giudicelli V, Chaume D, Lefranc G (2005) IMGT-Choreography for immunogenetics and immunoinformatics. In Silico Biol 5:45–60PubMedGoogle Scholar
  6. Lefranc M-P, Giudicelli V, Regnier L, Duroux P (2008) IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics. Brief Bioinform 9:263–275PubMedGoogle Scholar
  7. Pommié C, Levadoux S, Sabatier R, Lefranc G, Lefranc M-P (2004) IMGT standardized criteria for statistical analysis of immunoglobulin V-REGION amino acid properties. J Mol Recognit 17:17–32PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Laboratoire d’ImmunoGénétique Moléculaire, Institut de Génétique Humaine UPR 1142, Université Montpellier 2MontpellierFrance