Definition
Given a piece of tissue (or blood sample) and a family of protein(-epitope)s P 1, P 2,…, P k , TIS technology yields an “image stack”, that is, it yields a collection of k gray-value images that, for any position j in the sample under consideration, record the (relative) abundance f i (j) of protein P i (i = 1,…, k) at position j. In this context, information theory is used to “simplify” the data without sacrificing their essential “message” by identifying optimal families of thresholds that can be used for direct functional linkage analysis as they will highlight those combinations of proteins and “pathways” that are linked to, e.g., disease-specific or any other biologically important functional states of a cell (cf. Schubert 2002, 2003; Schubert et al. 2006, 2009).
Characteristics
Information-Theory Based Threshold Selection
Given a family of...
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References
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Dress, A. (2013). Information Theory and Toponomics. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_643
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_643
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