Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Pathway Modeling, Metabolic

  • Meghna Rajvanshi
  • Kareenhalli V. Venkatesh
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_585



Metabolic pathways or network is composed of a number of enzyme-catalyzed reactions that utilize substrate (such as glucose, sucrose, acetic acid, etc.) to demonstrate a characteristic phenotype (such as growth or adaptation to stress) and in the process accumulate products (such as amino acids, ethanol, lactic acid, etc.). Characterization and quantification of all the reaction rates ( Metabolic Flux Analysis) of the metabolic network comes under metabolic pathway modeling. Approaches like  metabolic flux analysis,  13C metabolic flux analysis,  flux balance analysis, and  metabolic pathway analysis are some of the approaches of metabolic pathway modeling, which assume pseudo-steady state condition for internal metabolites and are based on the principle of  mass balance. Through such modeling techniques, it is possible to study metabolic network properties, robustness, and fragility in the network....

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Meghna Rajvanshi
    • 1
  • Kareenhalli V. Venkatesh
    • 1
  1. 1.Department of Chemical EngineeringIndian Institute of Technology BombayPowai, MumbaiIndia