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Systems Virology

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Synonyms

Systems biology of viral pathogens; Systems biology of virus–host interactions

Definition

Systems Virology can be defined as the application of systems biology approaches and methods to the field of virology. The aim of Systems Virology is to develop a system-level understanding of viral infection, by focusing on the dynamic interplay between virus and host. A hallmark of Systems Virology approaches is the use of quantitative and dynamic mathematical models to simulate and predict viral interactions with the host, to develop a systems-level understanding of these interactions, and ultimately to identify new potential targets for antiviral drugs using model analysis. Systems Virology thus aims at the development and analysis of models of the influence of virus infection on cellular signaling pathways, of the role of specific viral and host genes in all steps of the viral life cycle, and of the host response to viral infection.

There is no clear boundary between systems biology...

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  • DOI: 10.1007/978-1-4419-9863-7_578
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References

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Correspondence to Narsis Aftab Kiani .

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Kiani, N.A., Kaderali, L. (2013). Systems Virology. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_578

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