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Encyclopedia of Systems Biology pp 2103–2106Cite as

Systems Pharmacology, Drug Disease Interactions

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Synonyms

Drug disease networks

Definition

Relationships between drugs and pathologies can be characterized in a comprehensive manner by interaction networks, giving a global view of drug disease interactions.

Characteristics

The relationships between drugs and diseases are complex. In the classical view, a particular drug used to be associated to a particular molecular target and to a particular treatment. However, cellular systems are highly interconnected by nature and this view is therefore incomplete. To obtain a comprehensive description of interactions between drugs, targets, and diseases, integrated approaches are needed where the relationships between all these components can be analyzed globally. Network approaches enable such analyses and have the potential to better explain the influence of drugs on diseases, as well as to understand interdependencies between drugs themselves (Spiro et al. 2008).

Network representations of drug–disease interactions necessitate...

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Systems Pharmacology, Drug Disease Interactions, Fig. 1

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Author information

Authors and Affiliations

  1. Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK

    Dr. Jean-Marc Schwartz

  2. Department of Information Science, Faculty of Science, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan

    Dr. Jose C. Nacher

Authors
  1. Dr. Jean-Marc Schwartz
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  2. Dr. Jose C. Nacher
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Corresponding author

Correspondence to Jean-Marc Schwartz .

Editor information

Editors and Affiliations

  1. Biomedical Sciences Research Institute, University of Ulster, Coleraine, UK

    Werner Dubitzky

  2. Department of Computer Science, University of Rostock, Rostock, Germany

    Olaf Wolkenhauer

  3. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea

    Kwang-Hyun Cho

  4. Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA

    Hiroki Yokota

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Schwartz, JM., Nacher, J.C. (2013). Systems Pharmacology, Drug Disease Interactions. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_575

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