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Systems Pathology

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Synonyms

Clinical systems pathology; Predictive pathology; Systems histopathology

Definition

Systems pathology is the study of disease through the integration of clinical, morphological, quantitative, and molecular parameters using mathematical analytical frameworks. The aim is to create coherent models which enable the understanding of pathophysiological processes in their entirety and generate hypotheses that can be tested experimentally. In practice, systems pathology aims to personalized therapy and predictive outcomes for patients (Personalized Medicine; Predictive Medicine).

Characteristics

Pathology is the study of mechanisms and diagnosis of disease and is the basis of all components of Laboratory Medicine including hematology, immunology, biochemistry, microbiology, genetics, and anatomic/histopathology. The word pathology comes from the Ancient Greek πάθος, pathos, “feeling, suffering”; and -λογία, -logia, “the study of.” Pathology addresses four main components of disease,...

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  • DOI: 10.1007/978-1-4419-9863-7_572
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References

  • Faratian D, Goltsov A, Lebedeva G, Sorokin A, Moodie S, Mullen P, Kay C, Um IH, Langdon S, Goryanin I, Harrison DJ (2009) Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab. Cancer Res 69:6713–6720

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  • Saidi O, Cordon-Cardo C, Costa J (2007) Technology Insight: will systems pathology replace the pathologist? Nat Rev Urol 4:39–45

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Correspondence to Dana Faratian .

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Faratian, D., Harrison, D. (2013). Systems Pathology. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_572

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