Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Pathway Targeting, Antimycobacterial Drug Design

  • Deepak Sharma
  • Avadhesha Surolia
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_568

Synonyms

Definition

Delineation of (mycobacterial) pathways/networks is essential for the identification of novel target(s) so as to hit the pathogen at its vulnerable weakest. In any given pathway or network, the potential (antitubercular) drug targets are the nonhomologous proteins that form (1) unique nodes including chokepoints (enzymes that uniquely consume/produce a metabolite) and (2) nodes with a high  degree centrality. For instance, the metabolic pathways/networks have been extensively implicated in antitubercular drug discovery over recent years (Ducati et al. 2007; Raman et al. 2009; Kim et al. 2010).

Characteristics

Tuberculosis (TB) has scourged the humankind for centuries, earning morbid nicknames such as The White Plague and The Captain of all the Men of Death. Robert Koch identified the causative agent, Mycobacterium tuberculosis, in 1882 and the first – and so far the only – vaccine against the disease, BCG (bacillus...

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Translational Health Science and Technology InstituteGurgaonIndia
  2. 2.Molecular Biophysics Unit, Indian Institute of ScienceBangaloreIndia