Definition
Positive autoregulation (PAR) occurs when a transcription factor enhances its own rate of production. As effects of PAR, response times are slowed and variation is usually enhanced. In the case of a strong PAR the motif may lead to bimodal distribution of protein levels in cell populations (Alon 2006, 2007).
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References
Alon U (2006) Introduction to systems biology: design principles of biological circuits. CRC, Boca Raton
Alon U (2007) Network motifs: theory and experimental approaches. Nat Rev Genet 8:450–461
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Lei, J. (2013). Positive Autoregulation. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_551
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_551
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